Genetic algorithms applied to translational strategy in metabolic-dysfunction associated steatohepatitis (MASH). Learning from mouse models
Ibon Martínez-Arranz, Cristina Alonso, Rebeca Mayo, Itziar Mincholé, José M. Mato, Dae-Jin Lee
Published in: Computer Methods and Programs in Biomedicine.
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One‐step non‐invasive diagnosis of metabolic dysfunction‐associated steatohepatitis and fibrosis in high‐risk population
Paula Iruzubieta, Rebeca Mayo, Itziar Mincholé, Ibon Martínez-Arranz, María Teresa Arias‐Loste, Luis Ibañez‐Samaniego, Javier Ampuero, Javier Abad, Rosa Martín‐Mateos, Ana Belén Fernández‐Laso, Agustín Albillos, Rafael Bañares, José Luis Calleja, Manuel Romero‐Gómez, Rocío Aller, Javier Crespo
Serum identification of At-Risk MASH: The Metabolomics-Advanced steatohepatitis fibrosis score (MASEF)
Mazen Noureddin, Emily Truong, Rebeca Mayo, Ibon Martínez-Arranz, Itziar Mincholé, Jesus M Banales, Marco Arrese, Kenneth Cusi, María Teresa Arias-Loste, Radan Bruha, Manuel Romero-Gómez, Paula Iruzubieta, Rocio Aller, Javier Ampuero, José Luis Calleja, Luis Ibañez-Samaniego, Patricia Aspichueta, Antonio Marín-Duce, Tatyana Kushner, Pablo Ortiz, Stephen A Harrison, Quentin M Anstee, Javier Crespo, José M Mato, and Arun J Sanyal
Published in: Hepatology 79(1):p 135-148, January 2024.
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Role of Intracellular Drug Disposition in the Response of Acute Myeloid Leukemia to Cytarabine and Idarubicin Induction Chemotherapy
Gabriela Rodríguez-Macías, Oscar Briz, Candela Cives-Losada, María C. Chillón, Carolina Martínez-Laperche, Ibon Martínez-Arranz, Ismael Buño, Marcos González-Díaz, José L. Díez-Martín, Jose J. G. Marin and Rocio I. R. Macias
Ibon Martínez-Arranz, Chiara Bruzzone, Mazen Noureddin, Ruben Gil-Redondo, Itziar Mincholé, Maider Bizkarguenaga, Enara Arretxe, Marta Iruarrizaga-Lejarreta, David Fernández-Ramos, Fernando Lopitz-Otsoa, Rebeca Mayo, Nieves Embade, Elizabeth Newberry, Bettina Mittendorf, Laura Izquierdo-Sánchez, Vaclav Smid, Jorge Arnold, Paula Iruzubieta, Ylenia Pérez Castaño, Marcin Krawczyk, Urko M Marigorta, Martine C Morrison, Robert Kleemann, Antonio Martín-Duce, Liat Hayardeny, Libor Vitek, Radan Bruha, Rocío Aller de la Fuente, Javier Crespo, Manuel Romero-Gomez, Jesus M Banales, Marco Arrese, Kenneth Cusi, Elisabetta Bugianesi, Samuel Klein, Shelly C Lu, Quentin M Anstee, Oscar Millet, Nicholas O Davidson, Cristina Alonso, José M Mato
Published in: Hepatology, 2022 Oct 76(4): 1121-1134
The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles
Roberto Matorras, Ibon Martinez-Arranz, Enara Arretxe, Marta Iruarrizaga-Lejarreta, Blanca Corral, Jone Ibañez-Perez, Antonia Exposito, Begoña Prieto, Felix Elortza, Cristina Alonso
Published in: Journal of Assisted Reproduction and Genetics, 2020 Feb 37(2): 385-394
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A novel serum metabolomic profile for the differential diagnosis if distal cholangiocarcinoma and pancreático ductal adenocarcinoma
Rocío IR Macías, Luis Muñoz-Bellvis, Anabel Sánchez-Martin, Enara Arretxe, Ibon Martínez-Arranz, Ainhoa Lapitz, M Laura Gutiérrez Adelaida La Casta, Cristina Alonso, Luis M González, Matías A Ávila, María L Martinez-Chantar, Rui E Castro, Luis Bujanda, Jesus M Bañales, Jose J.G. Marín.
Published in: Cancers, 2020
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Agonist of RORA Attenuates Non-Alcoholic Fatty Liver Progression in Mice via Upregulation of microRNA 122
`2020` Agonist of RORA Attenuates Non-Alcoholic Fatty Liver Progression in Mice via Upregulation of microRNA 122
Published in:
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CA19-9 capability as predictor of pancreatic cancer resectability in a Spanish cohort
Herreros-Villanueva M., Ruiz-Rebollo L., Montes M., Rodriguez-Lopez M., Francisco M., Cubiella J., Iyo E., Garabitos E., Martínez Moneo E., Martos M., de Madaria E., Martínez-Arranz I., García-Cougil M., Iglesias-Gómez A., Bujanda L.
Published in: Molecular Biology Report, 2020 Mar 47(3): 1583-1588.
Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis
Javier Michelena, Cristina Alonso, Ibon Martínez-Arranz, José Altamirano, Rebeca Mayo, Pau Sancho-Bru, Ramón Bataller, Pere Ginès, Azucena Castro, Juan Caballería,
Published in: Annals of Hepatology, Annals of Hepatology, 2019 Feb-Mar 18 (1): 144-154
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Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis
Enric Reverter, Juan José Lozano, Cristina Alonso, Annalisa Berzigotti, Susana Seijo, Fanny Turon, Anna Baiges, Mari Luz Martínez-Chantar, José M. Mato, Ibon Martínez-Arranz, Vincenzo La Mura, Virginia Hernández-Gea, Jaume Bosch, Juan Carlos García-Pagán,
Published in: Liver International, Jan. 13, 2019
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Plasma miRNAs signature validation for early detection of colorectal cancer
Marta Herreros-Villanueva, Saray Duran-Sanchon, Ana Carmen Martín, Rosa Pérez-Palacios, Elena Vila-Navarro, María Marcuello, Mireia Diaz-Centeno, Joaquín Cubiella, Maria Soledad Diez, Luis Bujanda, Angel Lanas, Rodrigo Jover, Vicent Hernández, Enrique Quintero, Juan José Lozano, Marta García-Cougil, Ibon Martínez-Arranz, Antoni Castells, Meritxell Gironella and Rocio Arroyo
Published in: Clinical and Translational Gastroenterology, Jan. 10, 2019
Serum metabolites as diagnostic biomarkers for cholangiocarcinoma, hepatocellular carcinoma and primary sclerosing cholangitis
Jesus M Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntane, Luis Muñoz‐Bellvis, Adelaida La Casta, Luis M Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez‐Arranz, Ainhoa Lapitz, Alvaro Santos‐Laso, Matias A Avila, Maria L Martínez‐Chantar, Luis Bujanda, Jose J G Marin, Bruno Sangro, Rocio I R Macias,
Published in: Hepatology
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Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice
Martine C. Morrison, Lars Verschuren, Kanita Salic, Joanne Verheij, Aswin Menke, Peter Y. Wielinga, Marta Iruarrizaga‐Lejarreta, Laurent Gole, Wei‐Miao Yu, Scott Turner, Martien P.M. Caspers, Ibon Martínez‐Arranz, Elsbet Pieterman, Reinout Stoop, Arianne van Koppen, Anita M. van den Hoek, José M. Mato, Roeland Hanemaaijer, Cristina Alonso, Robert Kleemann,
Published in: Hepatology Communications, Vol. 2, no. 12, 2018
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Targeted UPLC-MS metabolic analysis of human faeces reveals novel low-invasive candidate markers for colorectal cancer
Joaquin Cubiella, Marc Clos-Garcia, Cristina Alonso, Ibon Martínez-Arranz, Miriam Perez-Cormenzana, Ziortza Barrenetxea, Jesus Berganza, Isabel Rodríguez-Llopis, Mauro D'Amato, Luis Bujanda, Marta Diaz-Ondina, Juan M. Falcón-Pérez,
Published in: Cancers
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Metabolomic-based noninvasive serum tests to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts
Rebeca Mayo, Javier Crespo, Ibon Martínez-Arranz, Jesus M Banales, Mayte Arias, Itziar Mincholé, Rocío Aller de la Fuente, Raúl Jimenez-Agüero, Cristina Alonso, Daniel A de Luis, Libor Vitek, Jan Stritesky, Joan Caballería, Manuel Romero-Gómez, Antonio Martín-Duce, Jose Maria Mugüerza Huguet, José Ignacio Busteros-Buraza, Michael O. Idowu, Azucena Castro, M Luz Martínez-Chantar, Pablo Ortiz, Radan Bruha, Shelly C Lu, Pierre Bedossa, Mazen Noureddin, Arun J. Sanyal, José M Mato,
Published in: Hepatology Communications 2018 Jul; 2(7): 807--820
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Use of a Metabolomic Approach to Non-invasively Diagnose Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
Fernando Bril, Laura Millán, Srilaxmi Kalavalalli, Michael J. McPhaul, Michael P. Caulfield, Ibon Martínez-Arranz, Cristina Alonso, Pablo Ortíz Betes, José M Mato, Kenneth Cusi,
Role of aramchol in steatohepatitis and fibrosis in mice
Marta Iruarrizaga-Lejarreta, Marta Varela-Rey, David Fernández-Ramos, Ibon Martínez-Arranz, Teresa C Delgado, Jorge Simon, Virginia Gutiérrez-de Juan, Laura delaCruz-Villar, Mikel Azkargorta, José L. Lavin, Rebeca Mayo, Sebastiaan M. Van Liempd, Igor Aurrekoetxea, Xabier Buqué, Donatella Delle Cave, Arantza Peña, Juan Rodríguez-Cuesta, Ana M. Aransay, Felix Elortza, Juan M. Falcón-Pérez, Patricia Aspichueta, Liat Hayardeny, Mazen Noureddin, Arun J. Sanyal, Cristina Alonso, Juan Anguita, María Luz Martínez-Chantar, Shelly C. Lu, and José M. Mato,
Published in: Hepatology Communications, Volume 1, number 9, November 2017, Pages 911--927
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Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma
Ander Arbelaiz, Mikel Azkargorta, Marcin Krawczyk, Álvaro Santos-Laso, Ainhoa Lapitz, Maria J. Perugorria, Oihane Erice, Esperanza Gonzalez, Raúl Jimenez-Agüero, Adelaida Lacasta, César Ibarra, Alberto Sánchez-Campos, Juan P. Jimeno, Frank Lammert, Piotr Milkiewicz, Marco Marzioni, Rocio I.R. Macias, José J.G.Marín, Tushar Patel, Gregory J. Gores, Ibon Martinez, Félix Elortza, Juan M. Falcón-Pérez, Luis Bujanda, and Jesus M. Banales,
Published in: Hepatology, Volume 66, issue 4, October 2017, Pages 1125--1143
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A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients
Ainara Cano, Zoe Mariño, Oscar Millet, Ibon Martínez-Arranz, Miquel Navasa, Juan Manuel Falcón-Pérez, Miriam Pérez-Cormenzana, Joan Caballería, Nieves Embade, Xavier Forns, Jaume Bosch, Azucena Castro & José María Mato,
Published in: Scientific Reports 7, article number: 10497.
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Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
Alonso C, Fernández-Ramos D, Varela-Rey M, Martínez-Arranz I, Navasa N, Van Liempd SM, Lavin JL, Mayo R, Ilisso CP, de Juan VG, Iruarrizaga-Lejarreta M, delaCruz-Villar L, Mincholé I, Robinson A, Crespo J, Martín-Duce A, Romero-Gomez M, Sann H, Platon J, Van Eyk J, Aspichueta P, Noureddin M, Falcón-Pérez JM, Anguita J, Aransay AM, Martínez-Chantar ML, Lu SC, Mato JM.,
Published in: Gastroenterology, Volume 152, issue 6, May 2017, Pages 1449--1461.e7
Metabolically active extracellular vesicles released from hepatocytes under drug-induced liver-damaging conditions modify serum metabolome and might affect different pathophysiological processes
Felix Royo, Laura Palomo, Justyna Mleczko, Esperanza Gonzalez, Cristina Alonso, Ibon Martínez-Arranz, Miriam Pérez-Cormenzana, Azucena Castro, Juan M. Falcon-Perez,
Published in: European Journal of Pharmaceutical Sciences, Volume 98, February 2017, Pages 51--57
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis
Maite Martínez-Uña, Marta Varela-Rey, Ainara Cano, Larraitz Fernández-Ares, Naiara Beraza, Igor Aurrekoetxea, Ibon Martínez-Arranz, Juan L García-Rodríguez, Xabier Buqué, Daniela Mestre, Zigmund Luka, Conrad Wagner, Cristina Alonso, Richard H Finnell, Shelly C Lu, M Luz Martínez-Chantar, Patricia Aspichueta, José M Mato,
Published in: Hepatology, Octubre de 2013. HEPATOLOGY, Vol. 58, No. 4, 2013
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Solute carrier family 2 member 1 (SLC2A1) is involved in the development of nonalcoholic fatty liver disease
Vazquez-Chantada, M., Gonzalez-Lahera, A., Martinez-Arranz, I., Garcia-Monzon, C., Maria Regueiro, M., Garcia-Rodriguez, J.L., Karin Anna Schlangen, Mendibil, I., Rodriguez-Ezpeleta, N., Lozano, J.L., Karina Banasik, Johanne M Justesen, Torben Joergensen, Daniel R Witte, Torsten Lauritzen, Torben Hansen, Oluf Pedersen, Nicolas Veyrie, Karine Clement, Joan Tordjman, Albert Tran, Yannik Le Marchand-Brustel, Xabier Buque, Aspichueta, P., Echevarria-Uraga, J.J., Martin-Duce, A., Caballería, J., Philippe Gual, Castro, A., Mato, J.M., Martinez-Chantar, M.L., Aransay, A.M.,
Published in: Hepatology, Febrero de 2013. HEPATOLOGY, Vol. 57, No. 2, 2013
Metabolic profile associated with alcoholic hepatitis and the response to treatment. Preliminary results
Javier Michelena, Cristina Alonso, José Altamirano, Ibon Martínez-Arranz, Ramón Bataller, MariaLuz Martínez-Chantar, Azucena Castro, Jose M. Mato, Juan Caballería,
Published in: Journal of Hepatology, Volume 56, Supplement 2, Pages S535--S536
Barr, J., Caballería, J., Martínez-Arranz, I., Domínguez Díez, A., Alonso, C., Muntané, J., Pérez Cormenzana, M., García Monzón, C., Mayo, R., Martín Duce, A., Romero Gómez, M., Lo Iacono, O., Tordjman, J., Andrade, R.J., Pérez Carreras, M., le Marchand Brustel, Y., Tran, A., Fernández Escalante, C., Arévalo, E., García Unzueta, M., Clement, K., Crespo, J., Gual, P.,Gómez Fleitas, M., Martínez Chantar, M.L., Castro, A., S.C. Lu, Vázquez Chantada, M., Mato, J.M.,
Published in: Journal of Proteome Research, Febrero de 2012. J. Proteome Res. 2012, 11, 2521--2532